Glioblastoma Readout could mark a change for Diffusion Pharma

Published on March 15, 2024

Trending complete video highly rated pick Profitable Stocks, Pinks Sheets Penny Stocks, Invest Strategy, Great Penny Stocks, and DFFN Offering, Glioblastoma Readout could mark a change for Diffusion Pharma.

Diffusion Pharmaceuticals Inc. (DFFN) has a current market cap of $7.6 million, but on a fully diluted basis, it is $18.3 million after a stock offering was completed last week (the offering included $8 million worth of warrants at a $.35 strike price). If fully exercised, this provides 1.5 years (6 quarters) of operational cash, assuming the current burn rate of $3m per quarter. Investors participating in the most recent offering believed the study was likely to succeed, and so far, the data looks positive:

In the dose-ranging portion the Phase 3 Glioblastoma trial, DFFN announced that the largest dose showed an 86% survival rate for 6 out of the 7 patients at the 14 month mark, in inoperable glioblastoma. The drug combination has a very favorable safety profile. This survival rate can be compared to the average historical survival rate of 9.2 month in the control group. Based on Phase 2 survival curves, the 2-year readout for this trial could show 60% survival, versus 10.5% in the historical control group.


In a 2017 study, the incidence rate of cancers of the brain (gliomas) was approximately 23 Americans per 100,000. The standard of care is temozolomide and radiotherapy, as well as surgical resection. For relapsed glioblastoma, which is almost certain, temozolomide, radiotherapy, and bevacizumab (Avastin) is indicated.

The survival rate is approximately 30% two years post-diagnosis. This very poor survival rate gives the opportunity for TSC to make a difference.

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DFFN Offering

DFFN Offering, Glioblastoma Readout could mark a change for Diffusion Pharma.

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